Skin‐Inspired and Self‐Regulated Hydrophobic Hydrogel for Diabetic Wound Therapy

Diabetic wounds are refractory and recurrent diseases that necessitate the development of multifunctional dressings. Inspired by the structure and function of the skin, we herein delicately design a novel swollen hydrophobic hydrogel (QL@MAB) composed of hydrophobic methyl acrylate (MA) and (3-acrylamidophenyl)boronic acid (AAPBA) network and co-loaded with antioxidant quercetin (Q) and antibiotic levofloxacin (L) for efficient diabetic wound therapy. The hydrophobic MA segments undergo phase separation to form a dense "epidermis", ensuring prolonged drug diffusion, long-term water retention, and high water content. Meanwhile, the AAPBA segments generate glucose-labile "sweat pores" via borate ester bonds with…

• NN
  National Natural Science Foundation of China

  Award: 32301104