Spatial Isolation of Single Copper(I) Sites for Cascade Enzyme‐Like Catalysis and Simultaneous Ferroptosis/Cuproptosis Boosted Immunotherapy

ABSTRACT Nanozyme‐based immunogenic cell death (ICD) inducers that effectively induce a strong immune response via enzyme‐like process have attracted great attention, but how to ensure controllable active sites and maximize site utilization remains a problem. Here, we report a structurally well‐defined and highly functional single‐site copper(I) nanomodulators termed CuNTD, constructed by precisely anchoring atomically dispersed self‐assembly S‐Cu(I)‐S sites onto a two‐dimensional Ti 3 C 2 surface. Leveraging Cu + with a higher catalytic efficiency than Cu 2+ , CuNTD generates reactive oxygen species (ROS) storms through photothermal‐enhanced cascade catalysis, further inducing mitochondrial dysfunction,…

• NN
  National Natural Science Foundation of China

  Awards: 32301128, 82302351, 52203335, 82192865
• BA
  Basic and Applied Basic Research Foundation of Guangdong Province

  Award: 2021A1515220184