Alterations in PD-L1 succinylation shape anti-tumor immune responses in melanoma
Central South University · Xiangya Hospital Central South University · +4 more institutions
Abstract
Tumors undergo metabolic reprogramming to meet the energetic, synthetic and redox demands essential for malignancy, often characterized by increased glycolysis and lactate production. However, the role of mitochondrial metabolism in tumor immunity remains unclear. The present study integrates spatial transcriptomics, bulk transcriptomics and proteomics, revealing a strong link between the metabolite succinyl-CoA and tumor immunity as well as the efficacy of anti-programmed cell death protein-1 (PD-1) therapy in patients with melanoma. Elevated succinyl-CoA levels, through α-ketoglutarate or succinate supplementation, enhanced T cell-mediated tumor elimination, both in vitro and in vivo. Mechanistically,…
Citation impact
- FWCI
- 39.11
- Percentile
- 100%
- References
- 82
Authors
22- LLLong LiangCorresponding
Central South University, Xiangya Hospital Central South University
- XKXinwei Kuang
Central South University, Xiangya Hospital Central South University
- YHYi He
Central South University, Xiangya Hospital Central South University
- LZLin Zhu
Central South University, Xiangya Hospital Central South University
- PLPoyee Lau
Central South University, Xiangya Hospital Central South University
Topics & keywords
- Succinylation
- Biology
- Immune system
- Melanoma
- Immunology
- Cancer research
- Tumor immunology
- Immunotherapy