Tailoring Versatile Nanoheterojunction-Incorporated Hydrogel Dressing for Wound Bacterial Biofilm Infection Theranostics

Wound-infected bacterial biofilms are protected by self-secreted extracellular polymer substances (EPS), which can confer them with formidable resistance to the host’s immune responses and antibiotics, and thus delays in diagnosis and treatment can cause stubborn infections and life-threatening complications. However, tailoring an integrated theranostic platform with the capability to promptly diagnose and treat wound biofilm infection still remains a challenge. Herein, a versatile erbium-doped carbon dot-encapsulated zeolitic imidazolate framework-8 (Er:CDs@ZIF-8) nanoheterojunction (C@Z nano-HJ) is tailored and incorporated into gelatin methacrylate/poly(N-hydroxyethyl acrylamide) (GelMA/PHEAA)-based tough…

• NN
  National Natural Science Foundation of China

  Awards: 32271392, 22305098
• MO
  Ministry of Human Resources and Social Security
• SO
  Society of Hong Kong Scholars
• NS
  Natural Science Foundation of Sichuan Province

  Awards: 2024NSFSC0676, 2023NSFSC0333
• FR
  Fundamental Research Funds for the Central Universities