Extracellular Vesicles: A Review of Their Therapeutic Potentials, Sources, Biodistribution, and Administration Routes
Wuhan Union Hospital · Union Hospital · +2 more institutions
Abstract
Extracellular vesicles (EVs) participate in intercellular communication and play an essential role in physiological and pathological processes. In recent years, EVs have garnered significant attention as cell-free therapeutic alternatives, vectors for drug and gene delivery, biomarkers for disease diagnosis and prognosis, vaccine development, and nutraceuticals. The biodistribution of EVs critically influences their efficacy and toxicity. Therefore, this review aims to discuss the main factors influencing the biodistribution of unmodified EVs, highlighting their distribution patterns, advantages, limitations, and applications under different routes of administration. In addition, we provide a comprehensive…
Citation impact
- FWCI
- 38.63
- Percentile
- 100%
- References
- 166
Authors
4- XSXiaorong SuCorresponding
Wuhan Union Hospital, Union Hospital, Huazhong University of Science and Technology
- HWHongxiang Wang
Huazhong University of Science and Technology
- QLQiubai Li
Hubei University of Science and Technology, Wuhan Union Hospital, Union Hospital, Huazhong University of Science and Technology
- ZCZhichao Chen
Wuhan Union Hospital, Union Hospital, Huazhong University of Science and Technology
Topics & keywords
- Biodistribution
- Extracellular vesicles
- Vesicle
- Extracellular
- Pharmacology
- Biophysics
- Nanotechnology
- Chemistry
- Zero hunger