Comprehensive review of the expanding roles of the carnitine pool in metabolic physiology: beyond fatty acid oxidation
Hunan University · Hunan University of Traditional Chinese Medicine
Abstract
Traditionally, the carnitine pool is closely related to fatty acid metabolism. However, with increasing research, the pleiotropic effects of the carnitine pool have gradually emerged. The purpose of this review is to comprehensively investigate of the emerging understanding of the pleiotropic role of the carnitine pool, carnitine/acylcarnitines are not only auxiliaries or metabolites of fatty acid oxidation, but also play more complex and diverse roles, including energy metabolism, mitochondrial homeostasis, epigenetic regulation, regulation of inflammation and the immune system, tumor biology, signal transduction, and neuroprotection. This review provides an overview of the complex network of carnitine…
Citation impact
- FWCI
- 60.42
- Percentile
- 100%
- References
- 324
Authors
8Topics & keywords
- Beta oxidation
- Carnitine
- Physiology
- Bioinformatics
- Fatty acid
- Medicine
- Biochemistry
- Computational biology
- Zero hunger