Genetic compatibility and ecological connectivity drive the dissemination of antibiotic resistance genes
Chalmers University of Technology · University of Gothenburg · +1 more institution
Abstract
The dissemination of mobile antibiotic resistance genes (ARGs) via horizontal gene transfer is a significant threat to public health globally. The flow of ARGs into and between pathogens, however, remains poorly understood, limiting our ability to develop strategies for managing the antibiotic resistance crisis. Therefore, we aim to identify genetic and ecological factors that are fundamental for successful horizontal ARG transfer. We used a phylogenetic method to identify instances of horizontal ARG transfer in ~1 million bacterial genomes. This data was then integrated with >20,000 metagenomes representing animal, human, soil, water, and wastewater microbiomes to develop random forest models that can…
Citation impact
- FWCI
- 20.66
- Percentile
- 100%
- References
- 69
Authors
7- DLDavid LundCorresponding
Chalmers University of Technology, University of Gothenburg
- MPMarcos Parras-Moltó
Chalmers University of Technology, University of Gothenburg
- JSJuan S. Inda-Díaz
Chalmers University of Technology, University of Gothenburg
- SEStefan Ebmeyer
University of Gothenburg
- DGD. G. Joakim Larsson
University of Gothenburg
Topics & keywords
- Horizontal gene transfer
- Biology
- Mobile genetic elements
- Antibiotic resistance
- Phylogenetic tree
- Gene
- Genome
- Ecology
- Clean water and sanitation