Dual‐Atom Catalyst Au@S‐rGO for Rapid and Highly Sensitive Electrochemical Detection of Fentanyl in Serum

Fentanyl is a highly lethal emerging drug that requires urgent rapid trace detection. In this work, high-sensitivity detection of fentanyl is achieved by Au- and S-doped reduced graphene oxide (Au@S-rGO). Spherical electron microscopy revealed that Au and S existed in an atomically dispersed state. The possible configurations of S in Au@S-rGO, as well as the effects of different doping positions on the electron density of Au, are analyzed by Density functional theory (DFT) simulations. The co-modification of metal and nonmetal atoms significantly improves the catalytic activity of the electrode. The optimal electrode delivers a good linear relationship for fentanyl concentrations from 0.0291 to 38.2 µmol L-1,…

• NN
  National Natural Science Foundation of China

  Awards: 22466038, 82260654
• NS
  Natural Science Foundation of Yunnan Province

  Awards: 202303AC100021, 202201AT070256