Controlling Stereoselectivity with Noncovalent Interactions in Chiral Phosphoric Acid Organocatalysis

Chiral phosphoric acids (CPAs) have emerged as highly effective Brønsted acid catalysts in an expanding range of asymmetric transformations, often through novel multifunctional substrate activation modes. Versatile and broadly appealing, these catalysts benefit from modular and tunable structures, and compatibility with additives. Given the unique types of noncovalent interactions (NCIs) that can be established between CPAs and various reactants─such as hydrogen bonding, aromatic interactions, and van der Waals forces─it is unsurprising that these catalyst systems have become a promising approach for accessing diverse chiral product outcomes. This review aims to provide an in-depth exploration of the…

• CF
  Canada Foundation for Innovation
• CS
  China Scholarship Council
• UO
  University of British Columbia
• NS
  Natural Sciences and Engineering Research Council of Canada