Recent advances in mesoporous silica nanoparticle: synthesis, drug loading, release mechanisms, and diverse applications

Despite significant advancements in pharmaceutical sciences, conventional drug delivery system remains limited by issues like poor permeability, toxicity, suboptimal efficacy, and inadequate targeting. These challenges pose substantial barrier to effective treatment for complex conditions like cancer, heart problems, chronic pain management, etc. Mesoporous silica nanoparticle (MSN), with their remarkable structural tunability and multifunctionality, have emerged as a transformative solution in the realm of drug delivery system. This review delves into the state-of-the-art synthesis methods of MSNs including physical, chemical, top down and bottom-up approaches with particular attention to the widely used…