Inhaled Sedation in Acute Respiratory Distress Syndrome
Centre National de la Recherche Scientifique · Inserm · +38 more institutions
Abstract
Whether the use of inhaled or intravenous sedation affects outcomes differentially in mechanically ventilated adults with acute respiratory distress syndrome (ARDS) is unknown.
To determine the efficacy and safety of inhaled sevoflurane compared with intravenous propofol for sedation in patients with ARDS. Design, Setting, and Participants: Phase 3 randomized, open-label, assessor-blinded clinical trial conducted from May 2020 to October 2023 with 90-day follow-up. Adults with early moderate to severe ARDS (defined by a ratio of Pao2 to the fraction of inspired oxygen of
Citation impact
- FWCI
- 50.00
- Percentile
- 100%
- References
- 40
Authors
314- MJMatthieu JabaudonCorresponding
Centre National de la Recherche Scientifique, Inserm, Université Clermont Auvergne, Clinical Trial Investigators, Centre Hospitalier Universitaire de Clermont-Ferrand
- JQJean‐Pierre Quenot
Inserm, Université de Bourgogne, Clinical Trial Investigators, Centre d’Investigation Clinique 1436
- JBJulio Badié
Clinical Trial Investigators, L'Hôpital Nord Franche-Comté
- JAJules Audard
Clinical Trial Investigators, Centre Hospitalier Universitaire de Clermont-Ferrand
- SJSamir Jaber
Inserm, Université de Montpellier, Clinical Trial Investigators, Hôpital Saint Eloi
Topics & keywords
- Medicine
- Sedation
- Propofol
- Anesthesia
- Clinical endpoint
- ARDS
- Randomized controlled trial
- Fraction of inspired oxygen
- Good health and well-being