Precise nanoscale fabrication technologies, the “last mile” of medicinal development
Changchun University of Chinese Medicine · Jilin University · +1 more institution
Abstract
Nanotechnologies seek to overcome inherent deficiencies of conventional diagnosis and treatment, which attracted sustained attention and a limited number of nanomedicines approved by the FDA. However, the critical gaps in clinical translation remain, and nanomedicines that were initially heralded as magic bullets have yet to reach their realistic potential. The major obstacles of fabrication technologies may be overlooked in the nanoparticles' journey. Suboptimal manufacturing strategies partly hampered the inefficient transformation. In this review, we discuss the nanoparticle manufacturing strategies of "Top-Down" and "Bottom-Up" on precise nanoscale fabrication, including artificial intelligence introduced…
Citation impact
- FWCI
- 30.83
- Percentile
- 100%
- References
- 250
Authors
5Topics & keywords
- Mile
- Last mile (transportation)
- Nanoscopic scale
- Fabrication
- Computer science
- Nanotechnology
- Engineering
- Materials science