articleDiabetes Obesity and MetabolismMar 17, 2025HYBRID OA

Use of semaglutide and risk of non‐arteritic anterior ischemic optic neuropathy: A Danish–Norwegian cohort study

ESEmma SimonsenLCLars Christian LundMEMartin ErnstVHVidar HjellvikLHLászló Hegedüs

University of Southern Denmark · Norwegian Institute of Public Health · +6 more institutions

PubMed
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Abstract

Aims

To investigate the putative association between semaglutide and non-arteritic anterior ischaemic optic neuropathy (NAION).

Materials And Methods

Data from national health registries in Denmark (2018-2024) and Norway (2018-2022) were used to compare NAION risk in individuals with type 2 diabetes initiating semaglutide versus sodium-glucose co-transporter 2 inhibitors (SGLT-2is). A supplementary self-controlled analysis examined NAION risk among all semaglutide users. National estimates were pooled using a fixed-effects model.

Citation impact

44
total citations
FWCI
66.55
Percentile
100%
References
31
Citations per year

Authors

10

Topics & keywords

Topics
Keywords
  • Medicine
  • Semaglutide
  • Hazard ratio
  • Danish
  • Confidence interval
  • Internal medicine
  • Incidence (geometry)
  • Type 2 diabetes
UN Sustainable Development Goals
  • Good health and well-being
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Funding