A Randomized Trial of Automated Insulin Delivery in Type 2 Diabetes

Kudva, Yogish C.; Raghinaru, Dan; Lum, John W.; Graham, Timothy E.; Liljenquist, David R.; Spanakis, Elias K.; Pasquel, Francisco J.; Ahmann, Andrew; Ahn, David; Aleppo, Grazia; Blevins, Thomas; Kruger, Davida; Brown, Sue A.; Levy, Carol J.; Weinstock, Ruth S.; Steenkamp, Devin; Spaic, Tamara; Hirsch, Irl B.; Broyles, Frances E.; Rickels, Michael R.; Tsoukas, Michael A.; Raskin, Philip; Hatipoğlu, Betül; Desjardins, Donna; Terry, Adrienne; Singh, Lakshmi G.; Davis, Georgia M.; Schmid, Caleb; Kravarusic, Jelena; Coyne, Kasey; Casaubon, Luis; Espinosa, Valerie; Jones, Jaye K.; Estrada, Kathleen; Afreen, Samina; Levister, Camilla; O’Malley, Grenye; Liu, Selina; Marks, Sheryl; Peleckis, Amy J.; Pasqua, Melissa‐Rosina; Tardio, Vanessa; Kurek, Corey; Luker, Ryan; Churchill, Jade; Tajrishi, Farbod Zahedi; Dean, Ariel; Dennis, Brittany; Fronczyk, Evelyn; Perez, Jennifer; Mukhashen, Shereen; Dhillon, Jasmeen; Ipek, Aslihan; Bzdick, Suzan; Atakov-Castillo, Astrid; Driscoll, Marsha; Averkiou, Xenia; Dalton-Bakes, Cornelia; Moore, Adelyn; Jordan, Lin F.; Lesniak, Amanda; Pinsker, Jordan E.; Sasson-Katchalski, Ravid; Campos, Tiffany; Spanbauer, Charles; Kanapka, Lauren; Kollman, Craig; Beck, Roy W.

doi:10.1056/nejmoa2415948

articleNew England Journal of MedicineMar 19, 2025Closed access

A Randomized Trial of Automated Insulin Delivery in Type 2 Diabetes

YCYogish C. Kudva DRDan Raghinaru JWJohn W. Lum TETimothy E. Graham DRDavid R. Liljenquist

Mayo Clinic in Arizona · Jaeb Center for Health Research · +21 more institutions

PubMed

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Abstract

Background

Automated insulin delivery (AID) systems have been shown to be beneficial for patients with type 1 diabetes, but data are needed from randomized, controlled trials regarding their role in the management of insulin-treated type 2 diabetes.

Methods

In this 13-week, multicenter trial, adults with insulin-treated type 2 diabetes were randomly assigned in a 2:1 ratio to receive AID or to continue their pretrial insulin-delivery method (control group); both groups received continuous glucose monitoring (CGM). The primary outcome was the glycated hemoglobin level at 13 weeks.

Citation impact

61

total citations

FWCI: 55.45
Percentile: 100%
References: 23

Citations per year

Authors

68

Topics & keywords

Topics

Keywords

Type 2 diabetes
Randomized controlled trial
Insulin delivery
Insulin
Medicine
Internal medicine
Diabetes mellitus
Endocrinology

UN Sustainable Development Goals

Zero hunger

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Funding

TD
Tandem Diabetes Care