Extracellular vesicles in cancer´s communication: messages we can read and how to answer
Czech Academy of Sciences, Institute of Photonics and Electronics · Jan Evangelista Purkyně University in Ústí nad Labem · +1 more institution
Abstract
Extracellular vesicles (EVs) are emerging as critical mediators of intercellular communication in the tumor microenvironment (TME), profoundly influencing cancer progression. These nano-sized vesicles, released by both tumor and stromal cells, carry a diverse cargo of proteins, nucleic acids, and lipids, reflecting the dynamic cellular landscape and mediating intricate interactions between cells. This review provides a comprehensive overview of the biogenesis, composition, and functional roles of EVs in cancer, highlighting their significance in both basic research and clinical applications. We discuss how cancer cells manipulate EV biogenesis pathways to produce vesicles enriched with pro-tumorigenic…
Citation impact
- FWCI
- 31.43
- Percentile
- 100%
- References
- 371
Authors
6- ASAlena Semerádtová
Czech Academy of Sciences, Institute of Photonics and Electronics
- MLMichaela Liegertová
Jan Evangelista Purkyně University in Ústí nad Labem
- RHRegina Herma
Jan Evangelista Purkyně University in Ústí nad Labem
- MČMagdalena Čapková
Czech Academy of Sciences, Institute of Photonics and Electronics
- CBChiara BrignoleCorresponding
Istituto Giannina Gaslini
Topics & keywords
- Microvesicles
- Extracellular vesicles
- Tumor microenvironment
- Biology
- Cancer
- Metastasis
- Stromal cell
- Cancer cell