Barriers and Strategies for Oral Peptide and Protein Therapeutics Delivery: Update on Clinical Advances
Gangneung–Wonju National University
Abstract
Peptide and protein (PP) therapeutics are highly specific and potent biomolecules that treat chronic and complex diseases. However, their oral delivery is significantly hindered by enzymatic degradation, instability, and poor permeability through the gastrointestinal (GI) epithelium, resulting in low bioavailability. Various strategies have emerged as transformative solutions to address existing challenges, offering enhanced protection, stabilization, and absorption of PPs. These strategies primarily focus on two major challenges: protecting the PP against harsh conditions and enhancing permeation across the intestinal membrane. Innovative approaches such as pH modulation and incorporation of enzyme inhibitors…
Citation impact
- FWCI
- 42.73
- Percentile
- 100%
- References
- 154
Authors
2Topics & keywords
- Chemistry
- Bioavailability
- Nanotechnology
- Medicine
- Pharmacology
- Materials science