Bacterial cell wall-specific nanomedicine for the elimination of Staphylococcus aureus and Pseudomonas aeruginosa through electron-mechanical intervention

Personalized synergistic antibacterial agents against diverse bacterial strains are receiving increasing attention in combating antimicrobial resistance. However, the current research has been struggling to strike a balance between strain specificity and broad-spectrum bactericidal activity. Here, we propose a bacterial cell wall-specific antibacterial strategy based on an in situ engineered nanocomposite consisting of carbon substrate and decorated TiOx dots, termed TiOx@C. The fiber-like carbon substrate of TiOx@C is able to penetrate the bacterial membrane of Pseudomonas aeruginosa (P. aeruginosa), but not that of Staphylococcus aureus (S. aureus) due to its thicker bacterial wall, thus achieving bacterial…