Hetero‐Trimetallic Atom Catalysts Enable Targeted ROS Generation and Redox Signaling for Intensive Apoptosis and Ferroptosis
Harbin Engineering University · Harbin Medical University · +2 more institutions
Abstract
Reactive oxygen species (ROS) play crucial roles in cellular metabolic processes by acting as primary intracellular chemical substrates and secondary messengers for cellular signal modulation. However, the artificial engineering of nanozymes to generate ROS is restricted by their low catalytic efficiency, high toxicity, and off-target consumption. Herein, hetero-trimetallic atom catalysts (TACs) anchored on a stable symmetrical pyramid structure are designed in the presence of N and P surface ligands from cross-linked polyphosphazene interlayer-coated MIL-101(Fe). The 3D network TACs with a uniform dispersion of Cu, Co, and Fe hetero-single atoms effectively tailor the active sites to avoid metal sintering,…
Citation impact
- FWCI
- 16.99
- Percentile
- 100%
- References
- 68
Authors
9- SLSiyi Li
Harbin Engineering University
- EJE Jiaoting
Harbin Medical University, Third Affiliated Hospital of Harbin Medical University
- XZXiucheng Zhao
Harbin Engineering University
- RXRui Xie
Harbin Medical University, Third Affiliated Hospital of Harbin Medical University
- JWJiaming Wu
Harbin Medical University, Second Affiliated Hospital of Harbin Medical University
Topics & keywords
- Reactive oxygen species
- Redox
- Catalysis
- Cell biology
- Materials science
- Biophysics
- Oxidative stress
- Intracellular