Dynamic GelMA/DNA Dual‐Network Hydrogels Promote Woven Bone Organoid Formation and Enhance Bone Regeneration
Shanghai University · Shanghai Jiao Tong University · +3 more institutions
Abstract
Bone organoids, in vitro models mimicking native bone structure and function, rely on 3D stem cell culture for self-organization, differentiation, ECM secretion, and biomineralization, ultimately forming mineralized collagen hierarchies. However, their development is often limited by the lack of suitable matrices with optimal mechanical properties for sustained cell growth and differentiation. To address this, a dynamic DNA/Gelatin methacryloyl (GelMA) hydrogel (CGDE) is developed to recapitulate key biochemical and mechanical features of the bone ECM, providing a supportive microenvironment for bone organoid formation. This dual-network hydrogel is engineered through hydrogen bonding between DNA and GelMA,…
Citation impact
- FWCI
- 32.92
- Percentile
- 100%
- References
- 105
Authors
15Topics & keywords
- Self-healing hydrogels
- Materials science
- Organoid
- Biomedical engineering
- Cell biology
- Bone tissue
- Nanotechnology
- Biology