articleScientific ReportsMar 24, 2025GOLD OA

Highly sensitive cancer detection using an open D-channel PCF-based SPR biosensor

MAMahla AshrafianSOSaeed OlyaeeMSMahmood Seifouri

Shahid Rajaee Teacher Training University

PubMed
Indexed incrossrefdoajpubmed

Abstract

Surface plasmon resonance (SPR) is a technique utilized for the label-free detection of cancer cells. In this analysis, we introduce a photonic crystal fiber (PCF) designed with an open D-channel, featuring a layer of gold (Au) and titanium dioxide (TiO2) as the plasmonic material. This effectively reduces the gap between the fiber core and the gold layer, resulting in improved performance. Additionally, incorporating TiO2 between the gold and the silica substrate enhances their adhesion and contributes to a more robust structure. We conducted a comprehensive numerical analysis of the suggested biosensor utilizing the finite element method (FEM) integrated with perfectly matched layers (PML) within the COMSOL…

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46
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24.20
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100%
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49
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Authors

3

Topics & keywords

Topics
Keywords
  • Biosensor
  • Cancer detection
  • Computer science
  • Cancer
  • Biology
  • Nanotechnology
  • Materials science
  • Genetics
UN Sustainable Development Goals
  • Good health and well-being
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