articleNature MicrobiologyMar 26, 2025HYBRID OA

Metabolic modelling reveals the aging-associated decline of host–microbiome metabolic interactions in mice

LBLena BestTDThomas DostDEDaniela EsserSFStefano FlorAMAndy Mercado-Gamarra

Christian-Albrechts-Universität zu Kiel · University Hospital Schleswig-Holstein · +8 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Aging is accompanied by considerable changes in the gut microbiome, yet the molecular mechanisms driving aging and the role of the microbiome remain unclear. Here we combined metagenomics, transcriptomics and metabolomics from aging mice with metabolic modelling to characterize host-microbiome interactions during aging. Reconstructing integrated metabolic models of host and 181 mouse gut microorganisms, we show a complex dependency of host metabolism on known and previously undescribed microbial interactions. We observed a pronounced reduction in metabolic activity within the aging microbiome accompanied by reduced beneficial interactions between bacterial species. These changes coincided with increased…

Citation impact

43
total citations
FWCI
26.64
Percentile
100%
References
117
Citations per year

Authors

25

Topics & keywords

Topics
Keywords
  • Microbiome
  • Biology
  • Metabolomics
  • Host (biology)
  • Metagenomics
  • Transcriptome
  • Microbial metabolism
  • Gut microbiome
No related works found for this paper.

Funding