Cancer-Associated Fibroblasts Foster a High-Lactate Microenvironment to Drive Perineural Invasion in Pancreatic Cancer
Guangdong General Hospital · Guangdong Academy of Medical Sciences · +5 more institutions
Abstract
Perineural invasion (PNI) is a pivotal prognostic factor in pancreatic cancer, associated with aggressive tumor behavior and adverse patient outcomes. The recognized clinical impact of PNI highlights the need to better understand the molecular mechanisms underlying PNI-induced phenotypes. In this study, we isolated PNI-associated cancer-associated fibroblasts (pCAF), which demonstrated a markedly enhanced capacity to promote neural invasion in pancreatic cancer compared with non-PNI-associated CAFs. Single-cell, high-throughput sequencing and metabolomics data showed a significant upregulation of glycolysis in pCAFs, fostering a high-lactate tumor microenvironment conducive to cancer progression. pCAF-derived…
Citation impact
- FWCI
- 36.61
- Percentile
- 100%
- References
- 68
Authors
14- TLTingting LiCorresponding
Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital, Southern Medical University, South China University of Technology
- CHChonghui Hu
Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital
- THTianhao Huang
Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital, Southern Medical University
- YZYu Zhou
Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital
- QTQing Tian
Guangdong Academy of Medical Sciences, Southern Medical University, South China University of Technology
Topics & keywords
- Pancreatic cancer
- Cancer research
- Cancer
- Tumor microenvironment
- Glycolysis
- Cancer cell
- Perineural invasion
- Reprogramming
- No poverty