Decoding microglial immunometabolism: a new frontier in Alzheimer's disease research
Seoul National University · Convergence Research Center for Diagnosis Treatment and Care System of Dementia · +1 more institution
Abstract
Alzheimer's disease (AD) involves a dynamic interaction between neuroinflammation and metabolic dysregulation, where microglia play a central role. These immune cells undergo metabolic reprogramming in response to AD-related pathology, with key genes such as TREM2, APOE, and HIF-1α orchestrating these processes. Microglial metabolism adapts to environmental stimuli, shifting between oxidative phosphorylation and glycolysis. Hexokinase-2 facilitates glycolytic flux, while AMPK acts as an energy sensor, coordinating lipid and glucose metabolism. TREM2 and APOE regulate microglial lipid homeostasis, influencing Aβ clearance and immune responses. LPL and ABCA7, both associated with AD risk, modulate lipid…
Citation impact
- FWCI
- 41.68
- Percentile
- 100%
- References
- 374
Authors
3Topics & keywords
- Neuroinflammation
- Neurodegeneration
- Microglia
- Lipid metabolism
- Biology
- Glycolysis
- Pentose phosphate pathway
- Inflammation