A single-cell atlas reveals immune heterogeneity in anti-PD-1-treated non-small cell lung cancer

Liu, Zedao; Yang, Zhenlin; Wu, Junqi; Zhang, Wenjie; Sun, Yuxuan; Zhang, Chao; Bai, Guangyu; Li, Yang; Fan, Hongtao; Chen, Ya‐Wen; Zhang, Lei; Jiang, Ben‐Yuan; Liu, Xiaoyan; Ma, Xiaoshi; Tang, Wei; Liu, Chang; Qu, Yang; Yan, Li‐Xu; Zhao, Deping; Wu, Yi‐Long; He, Shun; Xu, Long; Peng, Lishan; Chen, Xiaowei; Zhou, Bolun; Zhao, Liang; Zhao, Zhangyi; Tan, Fengwei; Zhang, Wanting; Yi, Dingcheng; Li, Xiangjie; Gao, Qianqian; Zhang, Guangjian; Wang, Yongjie; Yang, Minglei; Fu, Honghao; Guo, Yongjun; Hu, Xueda; Cai, Qingyuan; Lu, Qi; Bo, Yufei; Peng, Hui; Tian, Zhigang; Chen, Chang; Zou, Chang; Zhu, Linnan; Cheng, Sijin; Zhang, Yi; Zhong, Wen‐Zhao; Chang, Chen; Gao, Shugeng; Zhang, Zemin

doi:10.1016/j.cell.2025.03.018

articleCellMar 27, 2025HYBRID OA

A single-cell atlas reveals immune heterogeneity in anti-PD-1-treated non-small cell lung cancer

ZLZedao Liu ZYZhenlin Yang JWJunqi Wu WZWenjie Zhang YSYuxuan Sun

Peking University · Chinese Academy of Medical Sciences & Peking Union Medical College · +22 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Tregs. Precursor exhausted T cells (Texp cells) correlated with recurrence-free survival, identifying a patient subgroup with reduced recurrence risk despite lack of MPR. Our study dissects TIME heterogeneity in response to chemoimmunotherapy, offering insights for NSCLC management.

Citation impact

total citations

FWCI: 76.06
Percentile: 100%
References: 61

Citations per year

Authors

ZL
Zedao LiuCorresponding
Peking University
ZY
Zhenlin Yang
Chinese Academy of Medical Sciences & Peking Union Medical College
JW
Junqi Wu
Tongji University, Shanghai Pulmonary Hospital
WZ
Wenjie Zhang
Peking University
YS
Yuxuan Sun
Peking University

Topics & keywords

Topics

Cancer Immunotherapy and Biomarkers100%
Single-cell and spatial transcriptomics100%
Immune cells in cancer100%

Keywords

Biology
Atlas (anatomy)
Immune system
Cell
Lung cancer
Cancer research
Immunology
Genetics

UN Sustainable Development Goals

Good health and well-being

No related works found for this paper.

Funding

CL
Changping Laboratory
SM
Shanghai Municipal Health Commission
Award: 2023ZZ02025
NN
National Natural Science Foundation of China
Awards: 82203827, 62203019, 92259303, 82102886, 82241235, 82072578, 91959000, 82102966, 82472808, 92474114, 82350121, 92259205, L2424217, 92459001, 82388201
CA
Chinese Academy of Sciences
Award: XDB0940302
PU
Peking University
SH
Shanghai Hospital Development Center
Award: SHDC22021217
CA
China Academy of Space Technology
Award: 2022QNRC001
CF
Center for Life Sciences
GP
Guangdong Provincial People's Hospital
Awards: KA0120231004, GDPPHYTP201902
BN
Beijing Nova Program
Awards: 20220484119, Z211100002121055
NK
National Key Research and Development Program of China
Awards: 2021YFE0110600, 2022YFE0141000, 2021YFC2500900, 2022YFC2505005, 2023YFF1204700