The clinical landscape of CAR NK cells

Chimeric antigen receptor (CAR) NK cell therapy has emerged as a promising alternative to CAR T cell therapy, offering significant advantages in terms of safety and versatility. Here we explore the current clinical landscape of CAR NK cells, and their application in hematologic malignancies and solid cancers, as well as their potential for treating autoimmune disorders. Our analysis draws from data collected from 120 clinical trials focused on CAR NK cells, and presents insights into the demographics and characteristics of these studies. We further outline the specific targets and diseases under investigation, along with the major cell sources, genetic modifications, combination strategies, preconditioning-…

• KB
  Kræftens Bekæmpelse

  Award: R343-A19791
• L
  Lundbeckfonden

  Award: R381-2021-1278
• OU
  Odense Universitetshospital
• SU
  Syddansk Universitet
• HL
  H. Lundbeck A/S