Nanozyme Cascade Self-Powered H 2 O 2 Strategy for Chemiluminescence Array Sensor to Monitor and Deactivate Multiple Bacteria

Early warning and deactivation of multiple bacteria are highly desirable to prevent pathogen-responsible bacterial infectious illnesses. Here, we developed a nanozyme cascade self-powered H2O2 strategy for a chemiluminescence (CL) array immunosensor to enable high-throughput and simultaneous monitoring of multiple bacteria as well as their deactivation. Specifically, a novel ZIF-67@CoFePBA yolk–shell nanozyme was synthesized through a dissociation and re-coordination mechanism, exhibiting significantly enhanced peroxidase (POD)-like activity due to the confinement and synergistic effects. ZIF-67@CoFePBA nanozyme was utilized to immobilize glucose oxidase (GOx) for constructing the nanozyme cascade self-powered…

• NN
  National Natural Science Foundation of China

  Awards: 82172345, 22474124, 81573220
• NS
  Natural Science Foundation of Jiangsu Province

  Awards: BK20221281, 20KJA150004, BK20221370
• SK
  State Key Laboratory of Analytical Chemistry for Life Sciences

  Award: SKLACLS2405
• YS
  YangZhou Science and Technology Bureau

  Award: YZ2022074
• GR
  Graduate Research and Innovation Projects of Jiangsu Province

  Award: KYCX22_3462