Nose‐to‐Brain Delivery of Circular RNA SCMH1‐Loaded Lipid Nanoparticles for Ischemic Stroke Therapy
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Abstract
Ischemic stroke represents one of the leading cerebrovascular diseases with a high rate of mortality and disability globally. To date, there are no effective clinical drugs available to improve long-term outcomes for post-stroke patients. A novel nucleic acid agent circSCMH1 which can promote sensorimotor function recovery in rodent and nonhuman primate animal stroke models has been found. However, there are still delivery challenges to overcome for its clinical implementation. Besides, its effects on post-stroke cognitive functions remain unexplored. Herein, lipid nanoparticle circSCMH1@LNP1 is established to deliver circSCMH1 and explore its therapeutic efficacy comprehensively. Distribution experiments…
Citation impact
44
total citations
- FWCI
- 27.46
- Percentile
- 100%
- References
- 66
Citations per year
Authors
15Topics & keywords
Topics
Keywords
- Neuroinflammation
- Stroke (engine)
- Nasal administration
- Medicine
- Clinical efficacy
- Neuroscience
- Pharmacology
- Inflammation
UN Sustainable Development Goals
- Good health and well-being
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