A phase 2a trial of the IL-33 monoclonal antibody tozorakimab in patients with COPD: FRONTIER-4

Background Interleukin-33 may have a role in COPD pathobiology. FRONTIER-4 ( NCT04631016 ) investigated tozorakimab (an anti-interleukin-33 monoclonal antibody) in patients with moderate-to-severe COPD with chronic bronchitis receiving dual or triple inhaled therapy. Methods FRONTIER-4 was a phase 2a, randomised, double-blind, placebo-controlled study. Patients received tozorakimab 600 mg or placebo subcutaneously every 4 weeks for 24 weeks. The primary end‑point was change in pre-bronchodilator forced expiratory volume in 1 s (FEV 1 ) from baseline to week 12. Secondary outcomes included post-bronchodilator FEV 1 , time-to-first COPD composite exacerbation event and safety. Results The intent-to-treat…

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  AstraZeneca