Advances in antimicrobial peptides: From mechanistic insights to chemical modifications
The Royal Free Hospital · University College London · +7 more institutions
Abstract
This review provides a comprehensive analysis of antimicrobial peptides (AMPs), exploring their diverse sources, secondary structures, and unique characteristics. The review explores into the mechanisms underlying the antibacterial, immunomodulatory effects, antiviral, antiparasitic and antitumour of AMPs. Furthermore, it discusses the three principal synthesis pathways for AMPs and assesses their current clinical applications and preclinical research status. The paper also addresses the limitations of AMPs, including issues related to stability, resistance, and toxicity, while offering insights into strategies for their enhancement. Recent advancements in AMP research, such as chemical modifications…
Citation impact
- FWCI
- 69.46
- Percentile
- 100%
- References
- 295
Authors
8- RYRen YangCorresponding
The Royal Free Hospital, University College London
- XMXiaohan Ma
Roland Hill (United Kingdom), University College London
- FPFeng Peng
Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital, Southern Medical University
- JWJin Wen
Shanghai Stomatological Hospital, Shanghai Ninth People's Hospital
- LWLatifa W. Allahou
University College London
Topics & keywords
- Antimicrobial
- Antimicrobial peptides
- Computational biology
- Biochemical engineering
- Chemistry
- Biology
- Microbiology
- Engineering