articleJAMAMar 30, 2025GREEN OA

Intravenous Ferric Carboxymaltose in Heart Failure With Iron Deficiency

Deutsches Herzzentrum der Charité · German Centre for Cardiovascular Research · +45 more institutions

PubMed
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Abstract

Importance

Uncertainty remains about the efficacy of intravenous iron in patients with heart failure and iron deficiency.

Objective

To assess the efficacy and safety of ferric carboxymaltose in patients with heart failure and iron deficiency. Design, Setting, and Participants: This multicenter, randomized clinical trial enrolled 1105 patients with heart failure (defined as having a left ventricular ejection fraction of ≤45%) and iron deficiency (serum ferritin level

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