reviewMoleculesMar 29, 2025GOLD OA

Advances in Antimicrobial Peptides: Mechanisms, Design Innovations, and Biomedical Potential

HZHe ZhangJLJing LvZMZhili MaJMJunfeng MaJCJing Chen

Jilin University

PubMed
Indexed incrossrefdoajpubmed

Abstract

This comprehensive review explores the advancements in the study of antimicrobial peptides (AMPs), highlighting their potential as promising alternatives to conventional antibiotics in the context of growing antibiotic resistance. AMPs are small molecular proteins found ubiquitously in nature, exhibiting broad-spectrum antimicrobial activity, including antibacterial, antiviral, and antifungal effects, and are vital components of the innate immune system. Due to their non-specific membrane-disrupting mechanism, AMPs are emerging as effective candidates for novel anti-infective agents. The integration of AMPs with biomaterials, such as nanoparticles, liposomes, polymers, and hydrogels, enhances their stability…

Citation impact

45
total citations
FWCI
40.58
Percentile
100%
References
193
Citations per year

Authors

5

Topics & keywords

Topics
Keywords
  • Antimicrobial peptides
  • Context (archaeology)
  • Antimicrobial
  • Biocompatibility
  • Innate immune system
  • Immune system
  • Biology
  • Computational biology
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