reviewJournal of Functional BiomaterialsApr 2, 2025GOLD OA

Application of Hydroxyapatite Composites in Bone Tissue Engineering: A Review

Jinan University · Guangdong Province Stomatological Hospital · +2 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

The treatment of bone defects is complicated by clinical conditions, such as trauma, tumor resection, and infection, which result in defects and impair the bone's regenerative capacity. Hydroxyapatite (HAp), the primary inorganic component of bone, possesses good biocompatibility and osteoconductivity. However, it has poor mechanical properties, a slow degradation rate, and limited functionality, necessitating combination with other materials to broaden its application scope. This paper summarizes the importance and properties of HAp composites and provides a categorized review of current research on HAp composites in bone tissue engineering. These composite scaffolds not only offer excellent mechanical…

Citation impact

73
total citations
FWCI
38.18
Percentile
100%
References
117
Citations per year

Authors

4

Topics & keywords

Keywords
  • Materials science
  • Biocompatibility
  • Bone tissue
  • Tissue engineering
  • Composite number
  • Composite material
  • Biomedical engineering
  • Medicine
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