articleAdvanced ScienceApr 2, 2025GOLD OA

Glycolysis‐Derived Lactate Induces ACSL4 Expression and Lactylation to Activate Ferroptosis during Intervertebral Disc Degeneration

KSKaiqiang SunYSY. ShiYCYan ChenSWShunmin WangLHLinhui Han

Shanghai Changzheng Hospital · Shanghai Jiao Tong University · +1 more institution

PubMed
Indexed incrossrefdoajpubmed

Abstract

The abnormal activation of the inflammatory microenvironment is frequently accompanied by metabolic changes that affect the development of various diseases. However, the relationship between metabolic reprogramming and intervertebral disc degeneration (IVDD) remains unclear. This study aims to reveal the metabolic changes in nucleus pulposus (NPCs) during IVDD and investigate the mechanism of glycolysis-derived lactate on NPCs. Single-cell RNA sequencing reveals that during IVDD, NPCs are characterized by excessively elevated glycolysis, and the resultant lactate causes the dysfunction of NPCs via ferroptosis activation. Mechanistically, lactate results in the transcription of Acyl-CoA Synthetase Long Chain…

Citation impact

42
total citations
FWCI
47.09
Percentile
100%
References
61
Citations per year

Authors

11

Topics & keywords

Topics
Keywords
  • Glycolysis
  • Biology
  • Reprogramming
  • Sirtuin
  • Gene silencing
  • Cell biology
  • Biochemistry
  • Metabolism
UN Sustainable Development Goals
  • Good health and well-being
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