Regulation of cellular senescence in tumor progression and therapeutic targeting: mechanisms and pathways
Central South University · Jiangxi Chest Hospital · +10 more institutions
Abstract
Cellular senescence, a stable state of cell cycle arrest induced by various stressors or genomic damage, is recognized as a hallmark of cancer. It exerts a context-dependent dual role in cancer initiation and progression, functioning as a tumor suppressor and promoter. The complexity of senescence in cancer arises from its mechanistic diversity, potential reversibility, and heterogeneity. A key mediator of these effects is the senescence-associated secretory phenotype (SASP), a repertoire of bioactive molecules that influence tumor microenvironment (TME) remodeling, modulate cancer cell behavior, and contribute to therapeutic resistance. Given its intricate role in cancer biology, senescence presents both…
Citation impact
- FWCI
- 56.17
- Percentile
- 100%
- References
- 373
Authors
9- BLBowei Liu
Central South University, Jiangxi Chest Hospital, National Clinical Research, Xiangya Hospital Central South University
- ZPZhigang Peng
Central South University, Jiangxi Chest Hospital, National Clinical Research, Xiangya Hospital Central South University
- HZHao Zhang
Dalian Medical University, Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University
- NZNan Zhang
Huazhong University of Science and Technology
- ZLZaoqu Liu
Chinese Academy of Medical Sciences & Peking Union Medical College
Topics & keywords
- Senescence
- Biology
- Context (archaeology)
- Cancer
- Tumor microenvironment
- Mediator
- Cancer research
- Phenotype