Synchronously Evoking Disulfidptosis and Ferroptosis via Systematical Glucose Deprivation Targeting SLC7A11/GSH/GPX4 Antioxidant Axis
Gynecologic Oncology Group · Jilin University · +5 more institutions
Abstract
Disulfidptosis and ferroptosis are recently identified programmed cell deaths for tumor therapy, both of which highly depend on the intracellular cystine/cysteine transformation on the cystine transporter solute carrier family 7 member 11/glutathione/glutathione peroxidase 4 (SLC7A11/GSH/GPX4) antioxidant axis. However, disulfidptosis and ferroptosis are usually asynchronous due to the opposite effect of cystine transport on them. Herein, systematic glucose deprivation, by both inhibiting upstream glucose uptake and promoting downstream glucose consumption, is proposed to synchronously evoke disulfidptosis and ferroptosis. As an example, Au nanodots and Fe-apigenin (Ap) complexes coloaded FeOOH nanoshuttles…
Citation impact
- FWCI
- 82.25
- Percentile
- 100%
- References
- 58
Authors
9- MZMengsi Zhang
Gynecologic Oncology Group, Jilin University, Theranostics (New Zealand), First Hospital of Jilin University
- HZHao Zheng
Jilin University, Jilin Medical University, State Key Laboratory of Supramolecular Structure and Materials
- XZXuanqi Zhu
Jilin University, Jilin Medical University, State Key Laboratory of Supramolecular Structure and Materials
- SLShuwei Liu
Jilin University, Theranostics (New Zealand), First Hospital of Jilin University
- HJHao Jin
Jilin University, Jilin Medical University, State Key Laboratory of Supramolecular Structure and Materials
Topics & keywords
- GPX4
- Antioxidant
- Glutathione
- Cell biology
- Chemistry
- Nanotechnology
- Biochemistry
- Materials science
- Zero hunger