One‐Step Symbiosis of Bimetallic Peroxides Nanoparticles to Induce Ferroptosis/Cuproptosis and Activate cGAS‐STING Pathway for Enhanced Tumor Immunotherapy
Harbin Engineering University · Chinese Academy of Sciences · +2 more institutions
Abstract
Abstract To improve the efficiency and application prospects of metal peroxides in tumor therapy, the synthesis of bimetallic peroxides via simple yet effective approaches will be highly significant. In this work, hyaluronic acid modified zinc‐copper bimetallic peroxides (ZCPO@HA) nanoparticles are synthesized through a one‐step symbiotic method by co‐hydrolysis of zinc acetate and copper acetate in weakly alkaline solution, followed by modification with sodium hyaluronate. Upon decomposition in the tumor microenvironment, ZCPO@HA nanoparticles can generate a considerable content of hydroxyl radical (·OH) by Fenton‐like reaction between Cu 2+ and self‐compensating hydrogen peroxide, while downregulating the…
Citation impact
- FWCI
- 39.29
- Percentile
- 100%
- References
- 68
Authors
15Topics & keywords
- Chemistry
- Tumor microenvironment
- Biochemistry
- Immune system
- Biology