The cGAS‒STING pathway in cancer immunity: mechanisms, challenges, and therapeutic implications

Innate immunity represents the body's first line of defense, effectively countering the invasion of external pathogens. Recent studies have highlighted the crucial role of innate immunity in antitumor defense, beyond its established function in protecting against external pathogen invasion. Enhancing innate immune signaling has emerged as a pivotal strategy in cancer therapy. The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway is a key innate immune signal that activates the immune response and exerts antitumor effects; this is primarily attributed to the DNA receptor function of cGAS, which recognizes exogenous DNA to activate downstream STING signaling. This, in turn,…

• HC
  Health Commission of Hunan Province
• NN
  National Natural Science Foundation of China

  Awards: 82203233, 82202966, 82472882, 82303534, 82173142, 82302987