Engineered Exosomes Loaded in Intrinsic Immunomodulatory Hydrogels with Promoting Angiogenesis for Programmed Therapy of Diabetic Wounds
Institute of Biomedical Science · Southwest Jiaotong University · +1 more institution
Abstract
Inducing rapid angiogenesis by delivering specific biological cues is critical for diabetic wound healing. Nevertheless, the angiogenesis is hindered by the inflammatory microenvironment, and the immune cells fail to orchestrate immune responses to wound healing. Herein, vascular endothelial growth factor (VEGF) plasmids-loaded macrophage exosomes (Exos) were fabricated and enfolded in injectable self-healing hydrogels for programmed therapy of diabetic wounds through sequentially intrinsically modulating the inflammatory microenvironment and promoting angiogenesis. The hydrogels, formed via dynamical Schiff base reactions using modified polysaccharides, intrinsically regulate the inflammatory microenvironment…
Citation impact
- FWCI
- 47.26
- Percentile
- 100%
- References
- 51
Authors
6- WHWei‐Chien Huang
Institute of Biomedical Science, Southwest Jiaotong University
- QGQianru Guo
Institute of Biomedical Science, Southwest Jiaotong University
- HWHongrong Wu
Institute of Biomedical Science, Southwest Jiaotong University
- YZYaxian Zheng
Third People's Hospital of Chengdu, Southwest Jiaotong University
- TXTao XiangCorresponding
Institute of Biomedical Science, Southwest Jiaotong University
Topics & keywords
- Self-healing hydrogels
- Microvesicles
- Angiogenesis
- Nanotechnology
- Materials science
- Medicine
- Cell biology
- Chemistry