Human proteome distribution atlas for tissue-specific plasma proteome dynamics

Malmström, Erik; Malmström, Lars; Hauri, Simon; Mohanty, Tirthankar; Scott, Aaron; Karlsson, Christofer; Gueto-Tettay, Carlos; Åhrman, Emma; Nozohoor, Shahab; Tingstedt, Bobby; Regnér, Sara; Elfving, Peter; Bjermer, Leif; Forsvall, Andreas; Doyle, Alexander; Magnusson, Mattias; Hedenfalk, Ingrid; Kannisto, Päivi; Brandt, Christian; Nilsson, Emma; Dahlin, Lars B.; Malm, Johan; Linder, Adam; Niméus, Emma; Malmström, Johan

doi:10.1016/j.cell.2025.03.013

articleCellApr 8, 2025HYBRID OA

Human proteome distribution atlas for tissue-specific plasma proteome dynamics

EMErik Malmström LMLars Malmström SHSimon Hauri TMTirthankar Mohanty ASAaron Scott

Lund University · Skåne University Hospital · +3 more institutions

PubMed

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Abstract

The plasma proteome is maintained by the influx and efflux of proteins from surrounding organs and cells. To quantify the extent to which different organs and cells impact the plasma proteome in healthy and diseased conditions, we developed a mass-spectrometry-based proteomics strategy to infer the tissue origin of proteins detected in human plasma. We first constructed an extensive human proteome atlas from 18 vascularized organs and the 8 most abundant cell types in blood. The atlas was interfaced with previous RNA and protein atlases to objectively define proteome-wide protein-organ associations to infer the origin and enable the reproducible quantification of organ-specific proteins in plasma. We…

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Keywords

Biology
Proteome
Computational biology
Tissue distribution
Proteomics
Cell biology
Bioinformatics
Biochemistry

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