Obesity accelerates cardiovascular ageing

A global obesity pandemic, coupled with an increasingly ageing population, is exacerbating the burden of cardiovascular disease. Indeed, clinical and experimental evidence underscores a potential connection between obesity and ageing in the pathogenesis of various cardiovascular disorders. This is further supported by the notion that weight reduction not only effectively reduces major cardiovascular events in elderly individuals but is also considered the gold standard for lifespan extension, in obese and non-obese model organisms. This review evaluates the intricate interplay between obesity and ageing from molecular mechanisms to whole organ function within the cardiovascular system. By comparatively…

• AP
  Association pour la Recherche sur le Cancer
• MF
  Mark Foundation For Cancer Research
• SF
  Seerave Foundation
• EC
  European Commission
• AN
  Agence Nationale de la Recherche

  Awards: ANR-23-CE44-0030, ANR-23-R4HC-0006, ANR-22-CE14-0066
• IN
  Institut National de la Santé et de la Recherche Médicale
• AS
  Austrian Science Fund
• FP
  Fondation pour la Recherche Médicale
• IU
  Institut Universitaire de France
• IN
  Institut National Du Cancer
• CI
  Cancéropôle Ile de France
• KG
  Karl-Franzens-Universität Graz
• MU
  Medizinische Universität Graz
• MD
  Ministère des Solidarités et de la Santé
• AN
  Association Neurofibromatoses et Recklinghause
• B
  BioTechMed-Graz
• FW
  Fiona Wood Foundation