articleNature MedicineApr 8, 2025HYBRID OA

Microbiome–metabolome dynamics associated with impaired glucose control and responses to lifestyle changes

HWHao WuBLBo‐Min LvLZLuqian ZhiYSYikai ShaoXLXinyan Liu

Fudan University · Huashan Hospital · +6 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Type 2 diabetes (T2D) is a complex disease shaped by genetic and environmental factors, including the gut microbiome. Recent research revealed pathophysiological heterogeneity and distinct subgroups in both T2D and prediabetes, prompting exploration of personalized risk factors. Using metabolomics in two Swedish cohorts (n = 1,167), we identified over 500 blood metabolites associated with impaired glucose control, with approximately one-third linked to an altered gut microbiome. Our findings identified metabolic disruptions in microbiome-metabolome dynamics as potential mediators of compromised glucose homeostasis, as illustrated by the potential interactions between Hominifimenecus microfluidus and Blautia…

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42
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FWCI
26.27
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100%
References
79
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Authors

12

Topics & keywords

Topics
Keywords
  • Metabolome
  • Microbiome
  • Metabolomics
  • Prediabetes
  • Type 2 diabetes
  • Biology
  • Disease
  • Diabetes mellitus
UN Sustainable Development Goals
  • Good health and well-being
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