Complete sequencing of ape genomes

Yoo, DongAhn; Rhie, Arang; Hebbar, Prajna; Antonacci, Francesca; Logsdon, Glennis A.; Solar, Steven J.; Antipov, Dmitry; Pickett, Brandon D.; Safonova, Yana; Montinaro, Francesco; Luo, Yanting; Malukiewicz, Joanna; Storer, Jessica M.; Lin, Jiadong; Sequeira, Abigail N; Mangan, Riley J.; Hickey, Glenn; Anez, Graciela Monfort; Balachandran, Parithi; Bankevich, Anton; Beck, Christine R.; Biddanda, Arjun; Borchers, Matthew; Bouffard, Gerard G.; Brannan, Emry O.; Brooks, Shelise; Carbone, Lucia; Carrel, Laura; Chan, Agnes P.; Crawford, Juyun; Diekhans, Mark; Engelbrecht, Eric; Feschotte, Cedric; Formenti, Giulio; Garcia, Gage H.; Gennaro, Luciana de; Gilbert, David M.; Green, Richard E.; Guarracino, Andrea; Gupta, Ishaan; Haddad, Diana; Han, Junmin; Harris, Robert S.; Hartley, Gabrielle A.; Harvey, William T.; Hiller, Michael; Hoekzema, Kendra; Houck, Marlys L.; Jeong, Hyeonsoo; Kamali, Kaivan; Kellis, Manolis; Kille, Bryce; Lee, Chul; Lee, Young Ho; Lees, William; Lewis, Alexandra P.; Li, Qiuhui; Loftus, Mark; Loh, Yong Hwee Eddie; Loucks, Hailey; Ma, Jian; Mao, Yafei; Martinez, Juan Francisco Iturralde; Masterson, Patrick; McCoy, Rajiv C.; McGrath, Barbara C.; McKinney, Sean; Meyer, Britta; Miga, Karen H.; Mohanty, Saswat K.; Munson, Katherine M.; Pál, Karol; Pennell, Matthew W.; Pevzner, Pavel A.; Porubskỳ, David; Potapova, Tamara; Rojas, Francisca; Rocha, Joana L.; Ryder, Oliver A.; Sacco, Samuel; Saha, Swati; Sasaki, Takayo; Schatz, Michael C.; Schork, Nicholas J.; Shanks, Cole; Smeds, Linnéa; Son, Dongmin R.; Steiner, Cynthia; Sweeten, Alexander P.; Tassia, Michael G.; Thibaud‐Nissen, Françoise; Torres-González, Edmundo; Trivedi, Mihir; Wei, Wenjie; Wertz, Julie; Yang, Muyu; Zhang, Panpan; Zhang, Shilong; Zhang, Yang; Zhang, Zhenmiao; Zhao, Sarah A; Zhu, Yixin; Jarvis, Erich D.; Gerton, Jennifer L.; Rivas-González, Iker; Paten, Benedict; Szpiech, Zachary A.; Huber, Christian D.; Lenz, Tobias L.; Konkel, Miriam K.; Yi, Soojin V.; Canzar, Stefan; Watson, Corey T.; Sudmant, Peter H.; Molloy, Erin K.; Garrison, Erik; Lowe, Craig B.; Ventura, Mario; O’Neill, Rachel J.; Koren, Sergey; Makova, Kateryna D.; Phillippy, Adam M.; Eichler, Evan E.

doi:10.1038/s41586-025-08816-3

articleNatureApr 9, 2025HYBRID OA

Complete sequencing of ape genomes

DYDongAhn Yoo ARArang Rhie PHPrajna Hebbar FAFrancesca Antonacci GAGlennis A. Logsdon

University of Washington · National Institutes of Health · +52 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

. Consequently, our understanding of the evolution of our species is incomplete. Here we present haplotype-resolved reference genomes and comparative analyses of six ape species: chimpanzee, bonobo, gorilla, Bornean orangutan, Sumatran orangutan and siamang. We achieve chromosome-level contiguity with substantial sequence accuracy (

Citation impact

120

total citations

FWCI: 71.87
Percentile: 100%
References: 121

Citations per year

Authors

123

DY
DongAhn YooCorresponding
University of Washington
AR
Arang Rhie
National Institutes of Health, National Human Genome Research Institute
PH
Prajna Hebbar
University of California, Santa Cruz
FA
Francesca Antonacci
University of Bari Aldo Moro
GA
Glennis A. Logsdon
University of Washington, University of Pennsylvania

Topics & keywords

Topics

Genomics and Phylogenetic Studies100%
Chromosomal and Genetic Variations100%
Primate Behavior and Ecology99%

Keywords

Biology
Genome
Evolutionary biology
Centromere
Segmental duplication
Genetics
Heterochromatin
Hominidae

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