articleNatureApr 9, 2025HYBRID OA

Towards conversational diagnostic artificial intelligence

Google (United States)

PubMed
Indexed incrossrefpubmed

Abstract

Abstract At the heart of medicine lies physician–patient dialogue, where skillful history-taking enables effective diagnosis, management and enduring trust 1,2 . Artificial intelligence (AI) systems capable of diagnostic dialogue could increase accessibility and quality of care. However, approximating clinicians’ expertise is an outstanding challenge. Here we introduce AMIE (Articulate Medical Intelligence Explorer), a large language model (LLM)-based AI system optimized for diagnostic dialogue. AMIE uses a self-play-based 3 simulated environment with automated feedback for scaling learning across disease conditions, specialties and contexts. We designed a framework for evaluating clinically meaningful axes of…

Citation impact

224
total citations
FWCI
107.74
Percentile
100%
References
82
Citations per year

Authors

26

Topics & keywords

Keywords
  • Milestone
  • Empathy
  • Objective structured clinical examination
  • Excellence
  • Diagnostic accuracy
  • Scale (ratio)
  • Medical education
  • Primary care
UN Sustainable Development Goals
  • Quality Education
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