Bimetallic Metal–Organic Framework Microneedle Array for Wound Healing through Targeted Reactive Oxygen Species Generation and Electron Transfer Disruption
University of Science and Technology Beijing · Biosensor (Italy) · +2 more institutions
Abstract
The development of reactive oxygen species (ROS)-based antibacterial strategies that overcome ROS's ultrashort diffusion distance and disrupt bacterial electron transfer represents a promising yet underexplored avenue for nonantibiotic therapies. In this study, we introduce an iron-copper bimetallic metal-organic framework (MOF) with peroxidase (POD)-like enzymatic activity engineered to integrate dual functionalities: bactericidal recognition and electron transfer disruption to synergistically enhance antibacterial efficacy. Mechanistic investigations reveal that boronic-acid-cis-diol interactions enable the MOF to selectively bind to bacterial membranes, where it generates localized ROS, effectively killing…
Citation impact
- FWCI
- 35.45
- Percentile
- 100%
- References
- 52
Authors
6- SSSirong Sun
University of Science and Technology Beijing
- XLXiangyu Liu
University of Science and Technology Beijing
- XMXiangdan MengCorresponding
University of Science and Technology Beijing
- ZYZhou YangCorresponding
University of Science and Technology Beijing
- XZXueji Zhang
Biosensor (Italy), Theranostics (New Zealand), Shenzhen University Health Science Center, University of Science and Technology Beijing
Topics & keywords
- Bimetallic strip
- Reactive oxygen species
- Electron transfer
- Wound healing
- Materials science
- Metal-organic framework
- Metal
- Nanotechnology
- Zero hunger