Tumor Microenvironment‐Responsive Polymer Delivery Platforms for Cancer Therapy
East China University of Science and Technology · Fudan University · +2 more institutions
Abstract
Most chemotherapeutic and bioimaging agents struggle with inadequate bioavailability, primarily due to their limited biocompatibility and lack of specificity in targeting, leading to low or decreased anticancer efficacy and inaccurate imaging. To surmount these obstacles, the development of stimuli-responsive polymer delivery platforms, predominantly leveraging the tumor microenvironment (TME), has emerged as a promising strategy. Therapeutic and diagnostic agents can be released controllably at the tumor site by virtue of the bond cleavage or hydrophobic to hydrophilic transformation of TME-sensitive linkages in TME-responsive systems, thus augmenting cancer treatment and imaging precision, while…
Citation impact
- FWCI
- 24.42
- Percentile
- 100%
- References
- 186
Authors
5- YSYiqi Shi
East China University of Science and Technology
- QYQianqian Yu
East China University of Science and Technology
- LTLijie Tan
East China University of Science and Technology, Fudan University, Fudan University Shanghai Cancer Center, Zhongshan Hospital
- QWQi Wang
East China University of Science and Technology, Fudan University, Zhongshan Hospital
- WZWei‐Hong ZhuCorresponding
East China University of Science and Technology
Topics & keywords
- Tumor microenvironment
- Drug delivery
- Cancer imaging
- Nanotechnology
- Cancer therapy
- Molecular imaging
- Aggregation-induced emission
- Cancer
- Good health and well-being