The bone microenvironment: new insights into the role of stem cells and cell communication in bone regeneration

Mesenchymal stem cells (MSCs) play a crucial role in bone formation and remodeling. Intrinsic genetic factors and extrinsic environmental cues regulate their differentiation into osteoblasts. Within the bone microenvironment, a complex network of biochemical and biomechanical signals orchestrates bone homeostasis and regeneration. In addition, the crosstalk among MSCs, immune cells, and neighboring cells-mediated by extracellular vesicles and non-coding RNAs (such as circular RNAs and micro RNAs) -profoundly influences osteogenic differentiation and bone remodeling. Recent studies have explored specific signaling pathways that contribute to effective bone regeneration, highlighting the potential of…

• UD
  Università degli Studi di Verona
• IN
  Instituto Nacional de Ciência e Tecnologia de Nanobiofarmacêutica

  Award: 2022.01199.PTDC
• FP
  Fundação para a Ciência e a Tecnologia

  Award: 2022.01199