Synthesis of Axially Chiral Compounds via Transition Metal-Catalyzed Atroposelective C–H Functionalization

Liao, Gang; Shi, Bing‐Feng

doi:10.1021/acs.accounts.5c00173

articleAccounts of Chemical ResearchApr 14, 2025Closed access

Synthesis of Axially Chiral Compounds via Transition Metal-Catalyzed Atroposelective C–H Functionalization

GLGang Liao BSBing‐Feng Shi

Zhejiang University

PubMed

Indexed incrossrefpubmed

Abstract

ConspectusAxially chiral skeletons are prevalent in natural products and biologically important compounds, and they are widely utilized as privileged scaffolds in enantioselective catalysis. Consequently, the catalytic atroposelective synthesis of enantiopure atropisomers has garnered considerable attention. A variety of synthetic strategies involving metal catalysis or organocatalysis have been developed. Among these elegant approaches, transition metal-catalyzed enantioselective C–H activation has emerged as an atom- and step-economical strategy to streamline the construction of axially chiral compounds in recent years.In this Account, we discuss our efforts in the atroposelective synthesis of different…

Citation impact

63

total citations

FWCI: 46.79
Percentile: 100%
References: 87

Citations per year

Authors

2

Topics & keywords

Topics

Keywords

Surface modification
Catalysis
Chemistry
Transition metal
Combinatorial chemistry
Organic chemistry
Physical chemistry

No related works found for this paper.