PRDM16-dependent antigen-presenting cells induce tolerance to gut antigens

Abstract The gastrointestinal tract is continuously exposed to foreign antigens in food and commensal microorganisms with potential to induce adaptive immune responses. Peripherally induced T regulatory (pT reg ) cells are essential for mitigating inflammatory responses to these agents 1–4 . Although RORγt + antigen-presenting cells (APCs) have been shown to programme gut microbiota-specific pT reg cells 5–7 , their definition remains incomplete, and the APC responsible for food tolerance has remained unknown. Here we identify an APC subset that is required for differentiation of both food- and microbiota-specific pT reg cells and for establishment of oral tolerance. Development and function of these APCs…