Shared pathway-specific network mechanisms of dopamine and deep brain stimulation for the treatment of Parkinson’s disease
Humboldt-Universität zu Berlin · Bernstein Center for Computational Neuroscience Berlin · +9 more institutions
Abstract
Deep brain stimulation is a brain circuit intervention that can modulate distinct neural pathways for the alleviation of neurological symptoms in patients with brain disorders. In Parkinson's disease, subthalamic deep brain stimulation clinically mimics the effect of dopaminergic drug treatment, but the shared pathway mechanisms on cortex - basal ganglia networks are unknown. To address this critical knowledge gap, we combined fully invasive neural multisite recordings in patients undergoing deep brain stimulation surgery with normative MRI-based whole-brain connectomics. Our findings demonstrate that dopamine and stimulation exert distinct mesoscale effects through modulation of local neural population…
Citation impact
- FWCI
- 45.19
- Percentile
- 100%
- References
- 118
Authors
20- TSThomas S. BinnsCorresponding
Humboldt-Universität zu Berlin, Bernstein Center for Computational Neuroscience Berlin, Freie Universität Berlin, Charité - Universitätsmedizin Berlin
- RMRichard M. Köhler
Humboldt-Universität zu Berlin, Freie Universität Berlin, Charité - Universitätsmedizin Berlin
- JVJonathan Vanhoecke
Humboldt-Universität zu Berlin, Freie Universität Berlin, Charité - Universitätsmedizin Berlin
- MCMeera Chikermane
Humboldt-Universität zu Berlin, Freie Universität Berlin, Charité - Universitätsmedizin Berlin
- MGMoritz Gerster
Humboldt-Universität zu Berlin, Max Planck Institute for Human Cognitive and Brain Sciences, Bernstein Center for Computational Neuroscience Berlin
Topics & keywords
- Deep brain stimulation
- Neuroscience
- Dopamine
- Parkinson's disease
- Neurostimulation
- Dopaminergic
- Brain stimulation
- Subthalamic nucleus
- Good health and well-being