CONSORT 2025 explanation and elaboration: updated guideline for reporting randomised trials

This is comment on: Hopewell S, et al. CONSORT 2025 explanation and elaboration: updated guideline for reporting randomised trials. BMJ. 2025 Apr 14;389:e081124. https://pubmed.ncbi.nlm.nih.gov/40228832 The CONSORT (2025) statement [1] writes about blinding as follows: “Unblinded outcome assessors may differentially assess subjective outcomes, and unblinded data analysts may introduce bias through the choice of analytical strategies, such as the selection of favourable time points or outcomes and by decisions to remove patients from the analyses. These biases have been well documented,” p.27 in [1]. One of the references to this statement, ref. no. 328, is to the trial by Karlowski, Chalmers et al. (1975) [2].…